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Ocular surface squamous neoplasia

Ocular surface squamous neoplasia presents as a spectrum from simple dysplasia to carcinoma in situ to invasive squamous cell carcinoma involving the conjunctiva as well as the cornea. It is a distinct clinical entity, although it has been known by a variety of different names throughout the literature Ocular surface squamous neoplasia is the most common tumour of the ocular surface. It is a spectrum of disease from intraepithelial dysplasia to invasive squamous cell carcinoma. Recent years have seen an increase in the use of topical chemotherapeutic agents to treat this condition, often as primary treatmen Ocular surface squamous neoplasia (OSSN) are important because they mimic many common indolent lesions like pterygium and have a potential for causing ocular and systemic morbidity and mortality. Ultraviolet-B light and human papilloma viruses have been proposed as major risk factors in the etiopathogensis. Anterio

Ocular surface squamous neoplasia - PubMe

  1. PrécisOf 25 patients with bilateral ocular surface squamous neoplasia, no identifiable risk factors were noted in 7 (28%) patients, and outcomes included tumor free survival (n = 20; 80%), binocular globe salvage (n = 16, 64%), and binocular vision salvage (n = 14; 56%)
  2. e the current standard of care in the treatment of ocular surface squamous neoplasia (OSSN) with particular regard to topical chemotherapeutic agents including mitomycin C, 5-fluorouracil, and interferon-α2b. Methods: A mail survey of the 325 physician members of the Ocular Microbiology and Immunology Group. Results: The survey response rate was 38%, and the average number.
  3. Conjunctival and Corneal Intraepithelial Neoplasia/Squamous Cell Carcinoma A spectrum of lesions can arise from the squamous epithelium of the conjunctiva and cornea, varying along a continuum from benign to malignant. Based on the patient's history and clinical presentation, a differential diagnosis can be deduced

Management Issues in Conjunctival Tumours: Ocular Surface

Ocular surface squamous neoplasia includes a spectrum of dysplasia, ranging from mild to invasive carcinoma of conjunctiva, limbus, and cornea. 4 It typically presents as a unilateral limbal lesion, which can appear papillomatous, gelatinous, or leukoplakic. When on the cornea, it may have an opalescent appearance Ocular surface squamous neoplasia (OSSN) can range from mild dysplasia to invasive squamous cell carcinoma. Traditionally, wide surgical excision with cryotherapy was the treatment of choice but increasingly there has been a shift towards topical chemotherapy as both primary therapy and as an adjunct to surgery Ocular surface squamous neoplasia is mostly unilateral and is seen in middle-aged and older male patients. Rarely, it is bilateral, and in the case of bilaterality, it is most commonly associated with immunosuppression or xeroderma pigmentosum 28, 29

Ocular surface squamous neoplasia (OSSN) is the most common non-pigmented malignancy of the ocular surface and is represented in a wide range of histologic diagnoses, ranging from mild epithelial dysplasia to invasive squamous carcinoma. Although surgical excision is still the gold standard for OSSN treatment, interest in conservative medical approaches is steadily growing Overview. Ocular surface squamous neoplasia, or OSSN, is a clinical spectrum often encountered in ophthalmic practice. The incidence varies depending on the population being studied, but is more common among less pigmented males with increased occupational ultraviolet (UV) exposure as well as among those living in closer proximity to the equator

Ocular Surface Squamous Neoplasia - dj

  1. The most frequently encountered non-pigmented tumor of the ocular surface is ocular surface squamous neoplasia (OSSN). Over the past two decades, the pharmacological management of OSSN has grown, with topical 5-fluorouracil, mitomycin, and interferon alpha 2b all being successfully used to treat this disease. Other agents, such as anti-vascular endothelial growth factor (VEGF), retinoic acid.
  2. Results: Ocular surface squamous neoplasia is the most common ocular tumour, with incidence rates ranging from 0.01 to 3.4 per 100 000 persons/year
  3. Purpose: To identify predictors of ocular surface squamous neoplasm (OSSN) recurrence after operative resection. Design: Retrospective case series. Participants: Three hundred eighty-nine consecutive patients who underwent excisional biopsy for OSSN lesions at the Bascom Palmer Eye Institute from January 1, 2001, to September 20, 2010
  4. Ocular surface squamous neoplasia (OSSN) is a common malignancy of the conjunctiva and cornea. It can be thought of as a skin cancer of the eye

INTRODUCTION • The term Ocular Surface Squamous Neoplasia [OSSN] presently refers to the entire spectrum of dysplastic, pre-invasive and malignant squamous lesions of the conjunctiva and cornea 3 Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjuctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. A number of risk factors,.. Ocular surface squamous neoplasia (OSSN) is the most common ocular surface tumour (Grossniklaus et al. 1987). Other synonymous terms include 'conjunctival epithelial neoplasia', 'ocular surface epithelial dysplasia' and 'conjunctival squamous cell neoplasia' (Lee & Hirst 1992; McDonnell et al Ocular surface squamous neoplasia (OSSN) constitutes a spectrum of epithelial squamous malignancies of the cornea and conjunctiva [ 1 ]. Lesions can be pre-invasive or invasive, depending on the..

Ocular surface squamous neoplasia in association with Crohn's disease. Correspondence to: Dr Devjyoti Tripathy, Ophthalmic Plastics, Orbit and Ocular Oncology, LV Prasad Eye Institute, MTC Campus, Patia, Bhubaneswar-751024. Odisha, India. A 54-year-old male patient reported to the ophthalmic plastics and ocular oncology clinic of our. Purpose. Sunlight-induced p53 mutations are known to contribute towards increased risk of ocular surface squamous neoplasia (OSSN). Stratifin (14-3-3σ)/HEM (human epithelial marker) is a p53-mediated inhibitor of cell cycle progression and has been shown to be a target of epigenetic deregulation in various carcinomas Ocular-surface tumors including benign pterygia and potentially invasive ocular-surface squamous neoplasia (OSSN) have a tendency to develop from the transition zone between two functionally distinct cell types, namely the corneal and conjunctival epithelia Ocular surface squamous neoplasia (OSSN) are important because they mimic many common indolent lesions like pterygium and have a potential for causing ocular and systemic morbidity and mortality. Ultraviolet-B light and human papilloma viruses have been proposed as major risk factors in the etiopathogensis

Identification of ocular surface squamous neoplasia by in

2 Ocular Surface Squamous Neoplasia Napaporn Tananuvat 1 and Nirush Lertprasertsuke 2 Departments of 1Ophthalmology and 2Pathology, Faculty of Medicine, Chiang Mai University, Thailand 1. Introduction The ocular surface is composed of the conjunctiva and the cornea Ocular surface squamous neoplasia (OSSN) is a term that encompasses the spectrum of conjunctival epithelial malignancies from mild, moderate, and severe conjunctival epithelial dysplasia, carcinoma in situ, to invasive squamous cell carcinoma (SCC) [].It most frequently occurs at the corneoscleral limbus and exposed areas of bulbar conjunctiva [] Ocular Surface Squamous Neoplasia[OSSN] - A Brief Review Introduction Though conjunctivaltumours are uncommon, their early diagnosis assumes great significance due to its malignant potential in a small minority1,4.The term Ocular Surface SquamousNeoplasia [OSSN]presently refers to the entire spectrum of dysplastic, pre-invasive and. Ocular surface squamous neoplasia (OSSN) is a spectrum of dysplastic disease of the cornea and conjunctiva ranging from carcinoma-in situ (conjunctival-corneal intra-epithelial neoplasia (CCIN)) to invasive squamous cell carcinoma (SCC). It is reported to be a common malignancy of the ocular surface, particularly in areas with hig

Ocular surface squamous neoplasia Courtesy of Dr Muhammad Sharjeel Gomal medical college Dera Ismail khan creator of famous YouTube channel sharjeel Eye,Dr Farooq ul Abidin Resident 3rd year AFIO fulabidin@gmail.com 2. Birkholz ES et al. Treatment of ocular surface squamous cell intraepithelial neoplasia with and without mitomycin C. Cornea. 2011;30:37-41. 3. Lee GA, Hirst LW. Ocular surface squamous neoplasia. Survey of Ophthalmology. 1995; 39:429-50. 4. Nelson KD, McSoley JJ. Clinical findings and management of conjunctival intraepithelial neoplasia En-plaque ocular surface squamous neoplasia in a patient with Crohn's disease (A) Temporal limbal ocular surface squamous neoplasia with keratin plaque and clinically apparent central pyogenic granuloma. (B) Invasive squamous cell carcinoma was noted on histopathology post excision (hematoxylin and . eosin stain, ×100 magnification). A Ocular surface squamous neoplasia (OSSN) includes a variety of dysplastic changes of the conjunctiva and cornea, ranging from benign dysplasia to carcinoma in situ to invasive squamous cell carcinoma [1, 2].Risk factors include ultraviolet (UV) light, immunosuppression, human immunodeficiency virus (HIV), human papillomavirus (HPV), mutations of p53, and older age [1,2,3]

Bilateral ocular surface squamous neoplasia: A study of 25

Ocular Surface Squamous Neoplasia. What Is Ocular Surface Squamous Neoplasia (OSSN)? OSSN is a malignant growth on the surface of the eye involving the conjunctiva and cornea. It can be thought of as a skin cancer of the eye, and is largely due to sun exposure over a long time. They can mimic pterygia but tend to cause less symptoms, have. TY - JOUR. T1 - Ocular surface squamous neoplasia. T2 - A review. AU - Basti, Surendra. AU - Macsai, Marian S. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Even though ocular surface squamous neoplasia (OSSN) has been recognized for well over a century, the past decade has witnessed advances that have helped rewrite many of the paradigms for the diagnosis and management of these lesions Method: A literature search was conducted using the search criteria 'ocular surface squamous neoplasia', 'diagnosis', 'epidemiology', 'pathogenesis' and 'risk factors'. Results: Ocular surface squamous neoplasia is the most common ocular tumour, with incidence rates ranging from 0.01 to 3.4 per 100 000 persons/year

The term ocular surface squamous neoplasia 1 (OSSN) encompasses conjunctival and corneal intraepithelial neoplasia (CCIN) through to invasive squamous cell carcinoma (SCC) of the ocular surface. Lesions usually occur at the limbus (Fig. 1), and presenting symptoms and signs may include irritation, a red eye, a raised gelatinous mass, and leukoplakia. 1, 2 Brisbane-based studies 3 have shown. Background Ocular surface squamous neoplasia (OSSN) is the most common ocular surface tumour. Diagnosis and management have traditionally been by excision biopsy. Recently there has been success with the use of topical chemo or immunotherapy, which has resulted in a move from invasive diagnosis by histology to an array of non-invasive diagnostic tests Background: Ocular surface squamous neoplasia (OSSN) is a unifying term used to describe conjunctival intra-epithelial neoplasia, squamous cell carcinoma in situ and invasive squamous cell carcinoma. Aim: The aim of this article was to describe the demographics, clinical features, pathogenesis and risk factors of OSSN. Method: A literature search was conducted using the search criteria. Purpose: This study was conducted to show diverse clinical presentation of ocular surface squamous neoplasia with a rare presentation of caruncle squamous cell carcinoma (SCC). Methods: All cases that had suspicious ocular lesion were included in the treatment study. A detailed history including demographic data was obtained. Clinical features regarding the type of lesion, location, and the.

Ocular Surface Squamous Neoplasia: A Standard of Care

  1. Squamous conjunctival neoplasia (SCN) is most commonly found in older white males (76%). The average age of patients affected by SCN is 56. This tumor, said to make up 14% of all primary ocular and orbital tumors is related to sun exposure. Sunlight, particularly ultraviolet-B (UV-B) radiation can cause DNA damage, mutations, and cancerous cells
  2. Ocular surface squamous neoplasia (OSSN) represents a rare spectrum of disease ranging from mild dysplasia to carcinoma in situ to invasive squamous cell carcinoma of the ocular surface involving the conjunctiva and the cornea, occurring usually in the interpalpebral area, mostly at the limbus. Prevalence of OSSN varies from 0.03-1.9 per million population depending on the geographic location
  3. Ocular Surgery News | Ocular surface squamous neoplasia encompasses the spectrum of pathological lesions ranging from preinvasive dysplasia to invasive squamous cell carcinoma.Recent advances in.
  4. further included invasive neoplasia. Ocular Surface Squamous Neoplasia (OSSN) was a term given by Lee and Hirst12 which has three grades: a) Benign dysplasia 1. Papilloma Pseudotheliomatous hyperplasia b) Pre-invasive OSSN 1. Conjunctival/corneal carcinoma in situ c) Invasive OSSN 1. Squamous carcinoma 2. Mucoepidermoid carcinom
  5. Ocular Surface Squamous Neoplasia - Part 1. Ocular surface squamous neoplasia presents as a spectrum from simple dysplasia to carcinoma in situ to invasive squamous cell carcinoma involving the conjunctiva as well as the cornea. It is a distinct clinical entity, although it has been known by a variety of different names throughout the literature
  6. Ocular surface squamous neoplasia. Mild dysplasia; the basal cells are disordered with increased nuclear sizes and coarse nuclear chromatin. B. Severe dysplasia; the epithelial cells are varied in shapes and sizes with large pleomorphic nuclei. C. Carcinoma in situ: the entire thickness of the epithelium is composed of dysplastic cells bearing.
  7. Summary Ocular surface squamous neoplasia (OSSN) is a spectrum of disease with the potential for visual loss and metastasis. It is a distinct clinical entity, although it has been known by a variety of different names throughout the literature. Most commonly it arises in the limbal region, occurring particularly in elderly males living closer.

Ocular Surface Neoplasia: Diagnosing and Treating

Ocular Surface Tumors - University of Iow

Ocular surface squamous neoplasia (OSSN) - IJOOO- Print ISSN No: - 2581-5024 Online ISSN No:- 2581-5016 Article DOI No:- 10.18231, IP International Journal of Ocular Oncology and Oculoplasty-IP Int J Ocul Oncol Oculoplasty. OSSN is the third most common conjunctival malignancy worldwide and is commonest in the tropics. It is a tumor of the. Resolved ocular surface squamous neoplasia after five subconjunctival injections. Dr. Karp said that she chose the initial dosage, administered three times weekly, because it was known to be safe. Ocular surface squamous neoplasia (OSSN) is a broad term encompassing conjunctival and corneal intraepithelial neoplasia (dysplasia and in situ carcinoma) and invasive squamous cell carcinoma. The most recent (fourth edition) World Health Organization Classification of Tumours of the Eye grades conjunctival epithelial dysplasia as mild, moderate, severe, and in situ, based on the extent of.

Ocular surface squamous neoplasia (OSSN) represents a range of pathologies of the ocular surface ranging from squamous epithelial dysplasia to invasive squamous cell carcinoma (SCC) arising from the conjunctiva, cornea or both [].While large-scale epidemiological studies are lacking as a whole, a study carried out by the United States National Cancer Institute estimated an annual incidence of. Seborrheic keratosis is a benign epithelial neoplasia that commonly occurs on the face and eyelids of middle-aged individuals. Its occurrence on the conjunctiva is rare. We report a case of conjunctival seborrheic keratosis that clinically resembled an ocular surface squamous neoplasia (OSSN) Ocular surface squamous neoplasia can often be diagnosed clinically. Incisional/excisional biopsies, impression cytology, confocal microscopy and ultra-high-resolution optical coherence tomography.

Ocular surface squamous neoplasia (OSSN) is the most common tumor affecting the ocular surface in adults . OSSN was a term suggested by Lee and Hirst to describe all primary dysplastic and carcinomatous lesions that originate from the epithelium of the cornea or conjunctiva [ 2 ] Histopathological examination revealed ocular surface squamous neoplasia in 96% of the participants. Among these 36% had carcinoma in situ, 36% had invasive squamous cell carcinoma, 18% had conjunctival/corneal intraepithelial neoplasia and 10% had associated pterygium clinically and on histology as well Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt. KW - Epidemiology. KW - Ocular surface squamous neoplasia

Ocular squamous cell carcinoma (SCC) is a form of neoplasia (e.g. cancer) affecting the eye of both animals and humans. Ocular SCC is relatively rare in humans, affecting 1 in 1,000,000 people in regions outside of Africa. Incidence is highest in Africa, due to increased rates of HIV and exposure to UV light, both of which are risk factors for. Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma-in-situ and invasive carcinoma (squamous cell carcinoma) which may or may not be associated with intraocular or orbital extension. 1,2 OS malignancies, such as OSSN, Kaposi's sarcoma, and non-Hodgkin's. Ocular surface squamous neoplasia (OSSN) encompasses a range of ocular surface diagnoses, including dysplasia, carcinoma in situ, and invasive squamous cell carcinoma (SCC). These tumors frequently present near the corneal limbus, though any portion of the conjunctiva and/or cornea can be involved [1]. Although OSSN is the most prevalent conjunctival malignancy in adults, it is still.

Pathology Outlines - Conjunctival intraepithelial neoplasi

Ocular surface squamous neoplasia (OSSN) is classically divided into conjunctival intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC). CIN is dysplasia of the ocular surface epithelium that has not yet invaded the substantia propria of the conjunctiva or Bowman layer of the cornea C69.02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2021 edition of ICD-10-CM C69.02 became effective on October 1, 2020. This is the American ICD-10-CM version of C69.02 - other international versions of ICD-10 C69.02 may differ. All neoplasms are classified in this chapter. Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22:687-704. Pola EC, Masanganise R, Rusakaniko S. The trend of ocular surface squamous neoplasia among ocular surface tumour biopsies submitted for histology from Sekuru Kaguvi Eye Unit, Harare between 1996 and 2000. Cent Afr J Med. 2003;49:1-4

Ocular surface squamous neoplasia 972 Journal of the College of Physicians and Surgeons Pakistan 2020, Vol. 30(09): 970-973 dysplasia, carcinoma in situ, and invasive squamous cell carci-noma of ocular surface. 1 OSSN is a very common tumor in North-west Pakistan which i Ocular Surface Squamous Neoplasia(OSSN) is an embrac-ing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea. It includes the spectrum of Dysplasia, Carcinoma in-situ (CIS) and Invasive Squamous Cell Carcinoma(SCC)(1-3) Introduction: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN) . The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular. The term ocular surface squamous neoplasia (OSSN) encompasses conjunctival and corneal intraepithelial neoplasia through to invasive squamous cell carcinoma of the ocular surface. The disease is related to prolonged exposure to solar ultraviolet light and has been proposed as an acquired immune deficiency syndrome-associated tumor Ocular surface squamous neoplasia (OSSN) is a term that encompasses a wide and varied spectrum of very rare dysplastic diseases of the cornea and conjunctiva with a picture ranging from conjunctival intraepithelial neoplasia (CIN), carcinoma in situ (CIS) to invasive squamous cell carcinoma (SCC) of conjunctiva and/or cornea

Clinical Presentation of Ocular Surface Squamous Neoplasia

Ocular surface tumors can be primarily one of three malignant or pre-cancerous neoplasia of the conjunctiva and cornea. These tumors are ocular surface squamous neoplasia (OSSN) (sometimes referred to colloquially as the skin cancer of the eye), ocular surface melanocytic tumors, or lymphoid tumors of the conjunctiva Conjunctival and Corneal Tumors: Ocular Surface Squamous Neoplasia. Fig. 16.1. A 52-year-old African woman was diagnosed with HIV, with a CD4 count of 56 × 10 6 /mm 3 and viral load >100,000 copies/mL. At presentation, a fleshy conjunctival growth extending onto the cornea was initially diagnosed as a pterygium ( a ) In East Africa, ocular surface squamous neoplasia (OSSN) is a relatively common and aggressive eye cancer affecting younger adults causing visual disability, high morbidity and even death. Management of OSSN is challenging: the cause is unclear, people with the disease often present late, early diagnosis is problematic and tumours frequently. Software-Based Analysis Aids Ocular Surface Squamous Neoplasia Diagnosis. Image processing software can help clinicians distinguish squamous cell carcinoma, seen here, from conjunctival intraepithelial neoplasia. Clinical markers, including HIV seropositivity and the presence of feeder vessels are key in identifying and differentiating invasive.

Conjunctival/Corneal Invasive Squamous Cell Carcinoma

Ocular surface squamous neoplasia - ScienceDirec

  1. A review of the pharmaco-therapy of ocular surface squamous neoplasia (OSSN) is presented, with a focus on topical treatments. The existing literature is evaluated and topical the use of 5-fluorouracil, interferon, and mitomycin is summarized. In addition, a paper on the use of high-resolution optical coherence tomography (HR-0CT) in detecting.
  2. There is a trend toward treating conjunctival lesions suspected to be ocular surface squamous neoplasia (OSSN) based on the clinical impression. OBJECTIVE: To describe the presentation of OSSN and identify clinical features that distinguish it from benign lesions and subsequently evaluate their recognizability
  3. Ocular surface squamous neoplasia (OSSN) is a spectrum of pathology ranging from noninvasive intraepithelial dysplasia of the conjunctiva and cornea to invasive squamous cell carcinoma (SCC).1 The limbal stem cells are the origin of OSSN, which normally arise in the interpalpebral region and involved the bulba
  4. To the Editor:Ocular surface squamous neoplasia (OSSN) includes conjunctival intraepithelial neopla-sia with dysplasia, conjunctival carcinoma in situ and conjunctival squamous cell carcinoma (SCC). The incidence of OSSN is approximately 2 per 100000 per year [1]. Documented cases of bilateral neopla-sia/dysplasia are rare [2]. OSSN has been.

The incidence of ocular surface squamous neoplasia (OSSN) is strongly associated with solar ultraviolet (UV) radiation, HIV and human papilloma virus (HPV). Africa has the highest incidence rates in the world. Most lesions occur at the limbus within the interpalpebral fissure particularly the nasal sector. The nasal limbus receives the highest intensity of sunlight Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma-in-situ and invasive carcinoma (squamous cell carcinoma) which may or may not be associated with intraocular o

Keywords: Ocular surface squamous neoplasia, Undocumented, Uninsured, Cost-e ffective treatment, Case report Background Ocular surface squamous neoplasia (OSSN) includes a variety of dysplastic changes of the conjunctiva and cor-nea, ranging from benign dysplasia to carcinoma in situ to invasive squamous cell carcinoma [1, 2]. Risk factors in OCULAR SURFACE SQUAMOUS NEOPLASIA. Ocular surface squamous neoplasia (OSSN) is a malignant growth on the surface of the eye. It is mainly due to increased sun exposure over a long period of time. OSSN may present either as an incidental finding of a routine eye examination or some patients may notice the growth or report irritation Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiation-induced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface

Ocular surface squamous neoplasia: outcomes following

The term ocular surface squamous neoplasia (OSSN) was first described in 1995 by Lee and Hirst to denote a spectrum of neoplasm originate from squamous epithelium ranging from simple dysplasia to invasive squamous cell carcinoma(SCC), involving the conjunctiva, the. Ocular surface squamous neoplasia (OSSN) is a spectrum of disease, on which few of the large series have been documented to address the role of chemotherapy and immunotherapy for the treatment of ocular surface squamous cell neoplasia, none in particular from the Pakistan, especially ; the role of interferon therapy in management of OSSN.As the.

Tumors of the conjunctiva | Basicmedical Key

Ocular Surface Squamous Neoplasia in an Anophthalmic

Introduction. The ocular surface squamous neoplasia (OSSN) is the most common type of ocular tumor. However, it is rare with an incidence of 8.4 per million people per year. 1 We report a case of a giant OSSN treated with topical 5-fluorouracil (5-FU) 1%. The treatment is a matter of debate, with a tendency toward the use of topical chemotherapeutic agents in recent years Ocular Surface Squamous Neoplasia (OSSN) is an umbrella term coined by Lee and Hirst that encompasses dysplasia, carcinoma in situ, intraepithelial neoplasia and Squamous Cell Carcinoma (SCC) of the cornea and/or conjunctiva. (1) It is the third most common ocular tumour after retinoblastoma and melanoma.. Ocular surface squamous neoplasia. Ophthalmol Clin North Am. 2005; 18(1):1-13, vii (ISSN: 0896-1549) Pe'er J. This article discusses ocular surface squamous neoplasia, a spectrum of malignancy that includes intraepithelial dysplasia, carcinoma in situ of the conjunctiva and cornea, and invasive squamous cell carcinoma

A Very Unusual Case of Ocular Surface Squamous Neoplasia

Ocular Surface Squamous Neoplasia Hiding in Primary

Ocular surface squamous neoplasia (OSSN) is the most common ocular tumour with an incidence ranging from 0.03 to 1.9 per 100,000 persons/year. The diagnosis is made on clinical suspicion and confirmed with anterior-segment optical coherence tomography (AS-OCT), cytology, or histology Squamous neoplasia of the ocular surface has a multifactorial etiology, with actinic exposure, immunosuppression, human papillomavirus infection, and xeroderma pigmentosa being associated.1,2 Topical chemotherapy with mitomycin C or interferon alfa-2b can be a useful adjunct in management.3,4 Keywords: Ocular surface squamous neoplasia, Carcinoma in-situ(CIS), Squamous cell carcinoma (SCC) Introduction: OSSN is an encompassing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea. It includes the spectrum of Dysplasia, Carcinoma in-situ (CIS) and Invasive SCC [1-3]. CI

Ocular Surface Squamous Neoplasia - mivisio

Ocular Surface Squamous Neoplasia (OSSN): benign, pre-malignant or malignant slowly progressive epithelial lesions of the conjunctiva and cornea (3) Risk factors include UV light exposure, immunocompromising conditions (i.e. AIDS or organ transplant recipient), HPV type 16, xeroderma pigmentosum, and stem cell therapy. (3 Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

Aim: We report a case of fungal keratitis and Ocular Surface Squalous Neoplasia (OSSN) occurring in a HIV positive patient. Method: A 32-year-old female patient presented with a non-healing ulcer, which was diagnosed as fungal keratitis. On examination her ocular surface also revealed OSSN on the nasal bulbar conjunctiva. Serological investigations revealed HIV positive status with CD 4 counts. Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi Spitzer, Martin S; Batumba, Nkume H; Chirambo, Tamara; Bartz‐Schmidt, Karl U; Kayange, Petros; Kalua, Khumbo; Szurman, Peter 2008-07-01 00:00:00 I ntroduction Sub‐Saharan Africa has just 10% of the.

Bilateral ocular surface squamous neoplasia with bilateral

Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise what are called ocular surface squamous cell neoplasias. SCC is the most common malignancy of the conjunctiva in the US, with a yearly incidence of 1-2.8 per 100,000. Risk factors for the disease are exposure to sun (specifically occupational. bs_bs_banner Clinical and Experimental Ophthalmology 2014; 42: 307-308 doi: 10.1111/ceo.12349 Editorial Ocular surface squamous neoplasia: to cut or not to cut The goal of treating ocular surface squamous neoplasia (OSSN) is to eliminate all neoplastic squamous epithelium and prevent recurrence without causing complications or side effects Interferon α 2b is a very effective topical chemotherapeutic drug for the treatment of ocular surface squamous neoplasia (OSSN) with minimal adverse effects. This clinical example highlights the important role of this drug in early, small, limbal, corneal and giant OSSN tumours Ocular surface squamous neoplasia (OSSN) is the most common malignant ocular surface disease in Africa.1e3 It ranges from small areas of conjunctiva intra-epithelial neoplasia (CIN) to large invasive squamous cell carcinoma (SCC).4 There has been a marked increase in the incidence of this disease in East Africa over the last couple of decades Ten patients with histopathological diagnosis of ocular surface squamous neoplasia (OSSN) were recruited. Their unstained biopsy OSSN specimens were investigated using a custom-built autofluorescence multispectral microscopy imaging system. The images were taken in 38 spectral channels spanning specific excitation (340 nm-510 nm) and emission.

Tumors of the ocular surface: A review Honavar SGTumors of the Conjunctiva | Ento KeyPHFI CEHJ » Advances in anterior segment examinationMorpheaform basal cell carcinoma - American Academy of

Traditionally, surgical excision has been the treatment of choice for ocular surface squamous neoplasia (OSSN). Recurrences after surgery are high. To reduce the risk of recurrence, adjuvant therapies have been increasingly used 1) The role of HPV in the genesis of squamous cell carcinoma of the cervix, (2) anogenital region, (3) carcinoma of the head and neck, (4) and oral mucosa is well established, but its role in ocular surface squamous neoplasia (OSSN) is still unclear PURPOSE: To identify predictors of ocular surface squamous neoplasm (OSSN) recurrence after operative resection. DESIGN: Retrospective case series. PARTICIPANTS: Three hundred eighty-nine consecutive patients who underwent excisional biopsy for OSSN lesions at the Bascom Palmer Eye Institute from January 1, 2001, to September 20, 2010 Ocular surface squamous neoplasia: terminology that is conceptually friendly but clinically perilous. Eye (Lond) 2014;28:507-9. Nanji AA, Moon CS, Galor A, et al. Surgical versus medical treatment of ocular surface squamous neoplasia: a comparison of recurrences and complications. Ophthalmology 2014;121:994-1000 Ocular surface squamous neoplasia (OSSN) is a broad term, which denotes a spectrum of malignancy arising from the surface layer of the eye (conjunctiva and cornea). It can be thought of as a skin cancer of the eye